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Methanesulfonic Acid Pharma Grade

Methanesulfonic Acid Pharma Grade (MSA Pharma Grade) combination of strong acidity, low volatility, non-oxidizing behaviour, high polarity and miscibility with water and polar solvents makes MSA a versatile reagent and acid catalyst. Consistent and reproducible quality supports pharmaceutical process development and validation. Particular attention is given to the very low and controlled levels of methanesulfonate ester impurities. Specifications and analytical requirements can be evaluated according to the customer’s process and applicable pharmaceutical quality framework.
Application areas
API Manufacturing
MSA Pharma Grade can be used as a reagent, acid catalyst or processing aid in the manufacture of active pharmaceutical ingredients and pharmaceutical intermediates. Its consistent purity supports reliable and reproducible processes.

MSA Pharma Grade can be used as a reagent, acid catalyst or processing aid in the manufacture of active pharmaceutical ingredients and pharmaceutical intermediates.

Its consistent purity supports reliable and reproducible processes.

API Manufacturing
Pharmaceutical Quality and Regulatory Support
MSA Pharma Grade is designed for pharmaceutical processes requiring consistent quality and rigorous impurity control. Analytical specifications, supporting documentation and customer-specific requirements can be evaluated according to the intended application and the applicable pharmaceutical quality framework.

MSA Pharma Grade is designed for pharmaceutical processes requiring consistent quality and rigorous impurity control.

Analytical specifications, supporting documentation and customer-specific requirements can be evaluated according to the intended application and the applicable pharmaceutical quality framework.

Pharmaceutical Quality and Regulatory Support
Pharmaceutical Synthesis
Strong acidity, low volatility and non-oxidizing behaviour make MSA suitable for pharmaceutical transformations requiring effective acid catalysis and controlled process conditions.

Strong acidity, low volatility and non-oxidizing behaviour make MSA suitable for pharmaceutical transformations requiring effective acid catalysis and controlled process conditions.

Pharmaceutical Synthesis
Mesylate Salt Formation
MSA can convert pharmaceutical bases into their corresponding mesylate salts. Salt formation may influence properties such as solubility, stability, crystallinity and processability, depending on the characteristics of the individual active ingredient.

MSA can convert pharmaceutical bases into their corresponding mesylate salts.

Salt formation may influence properties such as solubility, stability, crystallinity and processability, depending on the characteristics of the individual active ingredient.

Mesylate Salt Formation
Acid-Catalysed Reactions
MSA can be used in esterification, hydrolysis, condensation, cyclisation, dehydration and other acid-catalysed transformations. Its non-oxidizing nature can help limit unwanted oxidation reactions in selected processes.

MSA can be used in esterification, hydrolysis, condensation, cyclisation, dehydration and other acid-catalysed transformations.

Its non-oxidizing nature can help limit unwanted oxidation reactions in selected processes.

Acid-Catalysed Reactions
Controlled Impurity Profile
MSA Pharma Grade offers consistent quality and an extremely low and controlled level of methanesulfonate esters. Specific impurity requirements and analytical parameters can be evaluated according to the customer’s process and application.

MSA Pharma Grade offers consistent quality and an extremely low and controlled level of methanesulfonate esters.

Specific impurity requirements and analytical parameters can be evaluated according to the customer’s process and application.

Controlled Impurity Profile
High-Purity Fine Chemicals
MSA Pharma Grade is also suitable for the synthesis of high-purity fine chemicals where reagent variability or trace impurities may affect process performance or final product quality.

MSA Pharma Grade is also suitable for the synthesis of high-purity fine chemicals where reagent variability or trace impurities may affect process performance or final product quality.

High-Purity Fine Chemicals
Process Development
The combination of acidity, polarity, solubility and low volatility makes MSA a valuable option for the development and optimization of chemical processes, including the evaluation of alternatives to conventional organic or mineral acids.

The combination of acidity, polarity, solubility and low volatility makes MSA a valuable option for the development and optimization of chemical processes, including the evaluation of alternatives to conventional organic or mineral acids.

Process Development
A closer look at MSA Pharma Grade
Discover the key properties, benefits and typical reactions of MSA Pharma Grade
Key properties and benefits - Key properties and benefits

Key properties and benefits

  • Manufactured under a controlled and documented quality system
  • Reproducible batch-to-batch quality
  • Extremely low and controlled level of methanesulfonate esters
  • Analytical support for customer-specific impurity requirements
  • Technical and quality documentation available to support customer qualifications
Typical reactions - Typical reactions

Typical reactions

  • Fischer–Speier esterification
  • Beckmann rearrangement
  • Acid-catalysed hydrolysis
  • Condensation, cyclisation and dehydration
  • Acetalisation and deacetalisation
  • Mesylate salt formation
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